sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 344300
• Cas Number: 915754-88-0
• Formula: C₁₉H₂₆N₂O₄S₂
• Purity: ≥95% by HPLC
• Description: A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC 50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.

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