Met/Flt-3/VEGFR2 Tyrosine Kinase Inhibitor - CAS 888719-03-7 - Calbiochem
| Name | Met/Flt-3/VEGFR2 Tyrosine Kinase Inhibitor - CAS 888719-03-7 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 448103 |
| Cas Number | 888719-03-7 |
| Formula | C₂₅H₁₆F₂N₄O₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable pyrrolopyridine-pyridone compound that acts as a potent ATP-competitive inhibitor of Met, Flt-3 and VEGFR2 (IC 50 = 1.9, 4.0 and 27 nM, respectively), while exhibiting much reduced potency against Lck and c-Kit (IC 50 = 290 and 610 nM, respectively) and little or no activity agaisnt Cdk2/CycE, IGF-1R, InsR, MK-2, PKA, and PKCα (IC 50 >1 µM) |
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