CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem
| Name | CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 219673 |
| Cas Number | 421580-53-2 |
| Formula | C₂₁H₁₇ClN₄O₂S₂ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant |
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