STAT3 Inhibitor XII, SPI - Calbiochem

• Supplier: EMD Millipore
• Catalog: 573127
• Formula: Suppliedasatrifluoroacetatesalt.
• Purity: ≥95% by HPLC
• Description: A cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.