Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem
| Name | Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 124030 |
| Formula | C₄₀H₄₃N₇O₂•3HCl |
| Purity | ≥97% by HPLC (mixture of regioisomers) |
| Description | A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018 ) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC 50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC 50 > 50 µM) |
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