PIM1 Inhibitor III

Name PIM1 Inhibitor III
Supplier EMD Millipore
Catalog 526521
Formula C₂₈H₂₃N₅O₅Ru
Purity ≥95% by HPLC
Description The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC 50 = 0.5 and 3 nM for the (S) - and (R) -enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC 50 = 15 and 20 nM for the (S) - and (R) -enantiomer, respectively).
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