Name | PIM1 Inhibitor III |
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Supplier | EMD Millipore |
Catalog | 526521 |
Formula | C₂₈H₂₃N₅O₅Ru |
Purity | ≥95% by HPLC |
Description | The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC 50 = 0.5 and 3 nM for the (S) - and (R) -enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC 50 = 15 and 20 nM for the (S) - and (R) -enantiomer, respectively). |
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