Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem
| Name | Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 528884 |
| Cas Number | 321688-88-4 |
| Formula | C₁₈H₁₉NO₃ |
| Purity | ≥99% by HPLC |
| Description | A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC 50 ) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg. |
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