LTA4 Epoxide Hydrolase Inhibitor, ARM1 - Calbiochem
| Name | LTA4 Epoxide Hydrolase Inhibitor, ARM1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 530656 |
| Formula | C₁₆H₁₄N₂S |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable benzylphenyl-thiazolamine compound that selectively inhibits against the leukotriene (LT) A 4 epoxide hydrolase activity of LTA4H by occupying the same hydrophobic tunnel ( K i = 2.3 µM) targeted by LTA 4 ω-end, displaying much reduced potency against LTA4H aminopeptidase activity (% inhibition/[ARM1] = 0/100 µM & 35/1 mM; Substrate = 800 µM Pro-Gly-Pro) coordinated by E296 and the catalytic site Zn 2+ at the adjacent hydrophilic peptide substrate-binding cavity |
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