γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
| Name | γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 565790 |
| Cas Number | 209986-17-4 |
| Formula | C₂₇H₂₄F₂N₄O₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC 50 = 300 pM for Aβ 40 in CHO cells overexpressing wild type βAPP; 240 pM for Aβ 40 , 370 pM for Aβ 42 , and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP 695 and mNotchΔE(M1727V); 100 pM for both Aβ 40 and Aβ 42 in SH-SY5Y cells stably transfected with SPA4CT) |
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