InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem
| Name | InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 444968 |
| Cas Number | 391210-10-9 |
| Formula | A50mM(5mg/207µl)solutionofMEK1/2InhibitorIII, |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays |
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