PERK Inhibitor I, GSK2606414 - CAS 1337531-89-1 - Calbiochem
| Name | PERK Inhibitor I, GSK2606414 - CAS 1337531-89-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 516535 |
| Cas Number | 1337531-89-1 |
| Formula | C₂₄H₂₀F₃N₅O |
| Purity | ≥99% by HPLC |
| Description | A cell-permeable pyrrolopyrimidinamine compound that acts as a highly potent inhibitor against EIF2AK3/PERK-catalyzed EIF2α Ser51 phosphorylation in kinase assays (IC 50 = 0.4 nM; 30 min preincubation; [ATP] = 5 µM) as well as ER stress-induced PERK autophosphorylation following Thapsigargin (Cat. No. 586005 ) addition in A549 cultures (by 100% with ≤30 nM inhibitor; 60 min preincubation) by targeting PERK in its inactive conformation at the ATP-binding region |
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