| Description |
A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca 2+ release-activated Ca 2+ ) channel-mediated SOCE (store-operated Ca 2+ entry) in RBL-2H3 cells (IC 50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca 2+ entry) in TRPC3-expressing HEK293 cells (IC 50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3)
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