Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem
| Name | Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 252790 |
| Cas Number | 120964-45-6 |
| Formula | Suppliedasahydrochloridesalt. |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable compound that is shown (at 1 µM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures |
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