PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
| Name | PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 493800 |
| Cas Number | 90417-38-2 |
| Formula | C₉H₈N₂O₂ |
| Purity | ≥98% by HPLC |
| Description | A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC 50 = 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines. |
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