PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 476495
• Cas Number: 521937-07-5
• Formula: C₁₂H₁₁NO₃
• Purity: ≥95% by HPLC
• Description: A cell-permeable benzoxoloazepinolone compound that effectively inhibits syntide-2 (Cat. No. 05-23-4910) phosphorylation by all three PKD/PKCµ isoforms 1, 2, & 3 (IC 50 = 182, 280, and 227 nM, respectively), while exhibiting ≥30-fold less potency towards Cdk activating kinase, Plk1, CaMKIIα, as well as 44 other kinases, 33 of which are not significantly inhibited even at concentrations as high as 10 µM, including Akt1/2 and PKCα/β/δ/ζ

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