JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
| Name | JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 420148 |
| Cas Number | 1260181-14-3 |
| Formula | C₂₇H₂₅F₃N₄O₄ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3β, JAK3, PKCα and PKCθ (IC 50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC 50 = 1.017, 2.55 and 8.055 µM, respectively) |
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