JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 420143
• Cas Number: 1164153-22-3
• Formula: C₂₇H₂₇N₅O₅
• Purity: ≥95% by HPLC
• Description: A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC 50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC 50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC 50 = 1.3 µM).

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