Sirt1 Inhibitor VII, Inauhzin - Calbiochem
| Name | Sirt1 Inhibitor VII, Inauhzin - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 566332 |
| Formula | C₂₅H₁₉N₅OS₂ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable phenothiazine derivative that selectively inhibits SirT1 (IC 50 ≤2.0 µM), but not SirT2, SirT3, or HCAC8 (IC 50 >50 µM), activity and effectively elevates cellular p53 lysine acetylation (Effective conc. 2 µM), thereby protecting p53 lysine residues from MDM2-mediated ubiquitination without directly inhibiting MDM2 function per se or its activity toward deacetylated p53 |
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