Importazole - Calbiochem

Name Importazole - Calbiochem
Supplier EMD Millipore
Catalog 401105
Formula C₂₀H₂₂N₄
Purity ≥98% by HPLC
Description A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC 50 = 15 µM against Ca +2 -induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export
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