EF24 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 324510
• Formula: C₁₉H₁₅F₂NO
• Purity: ≥97% by HPLC
• Description: A cell-permeable Curcumin (Cat. No. 239802 ) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC 50 = 1.9 vs. 20 µM, respectively) and in blocking TNFα-induced cellular I-κB phosphorylation (IC 50 = 5.7 vs. >50 µM, respectively) and NF-κB nuclear translocation (IC 50 = 1.3 vs. 13 µM, respectively) in A549 cultures, as well as in its anticancer activity (EC 50 ranges from 0.44 to 2.07 µM against various cancer cell lines)