Tau Aggregation Inhibitor, ATPZ, Cpd16 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 580222
• Formula: C₁₆H₁₃ClN₄O₂S
• Purity: ≥95% by HPLC
• Description: A water soluble (32 µM in water) BBB-permeable ATPZ (aminothienopyridazine) tau aggregation inhibitor that exhibited IC 50 of 8.1 µM in a heparin-induced tau assembly assay (monitored by thioflavine-T binding and fluorescence), and was further validated in vitro to reduce tau fibril formation (tau fragment K18PL, and full length tau40) by >50% in sedimentation assays