γ-Secretase Inhibitor XII - Calbiochem

Name γ-Secretase Inhibitor XII - Calbiochem
Supplier EMD Millipore
Catalog 565773
Formula C₂₀H₃₀N₂O₄
Purity ≥95% by HPLC
Description A cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ 40 IC 50 = 7.9 µM; Aβ 42 IC 50 = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ 40 IC 50 = 11.5 µM; Aβ 42 IC 50 = 8.3 µM)
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