JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem
| Name | JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 420145 |
| Cas Number | 796041-65-1 |
| Formula | C₂₃H₂₀ClN₃O |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures |
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