Tankyrase1/2 Inhibitor, XAV939 - Calbiochem
| Name | Tankyrase1/2 Inhibitor, XAV939 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 575545 |
| Formula | C₁₄H₁₁F₃N₂OS |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable dihydrothiopyranopyrimidinol that binds TNKS1/PARP5a and TNKS2/PARP5b with high affinity (K d = 99 and 93 nM, respectively) and potently inhibits their PARsylation (poly ADP-ribosylation) activity (IC 50 = 11 and 4 nM, respectively), while exhibiting much lower activity against PARP1 and PARP2 (IC 50 = 2.194 and 0.114 µM, respectively) |
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