Tubulin Polymerization Inhibitor II
| Name | Tubulin Polymerization Inhibitor II |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 654164 |
| Cas Number | 1151995-69-5 |
| Formula | C₁₉H₁₉NO₅ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC 50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI 50 <10 nM for 46 lines among a 53 NCI panel tested). |
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