Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 217707
• Cas Number: 845714-00-3
• Formula: C₁₂H₁₁N₃O
• Purity: ≥90% by HPLC
• Description: A cell-permeable pyrrolopyridinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9 (IC 50 = 10 and 34 nM, respectively) with good selectivity over a panel of 31 other kinases, including GSK-3β, Cdk2, Cdk1, Cdk5, MK-2, Plk1, and Chk2 (IC 50 = 0.22, 0.24, 0.25, 0.46, 0.47, 0.98, and 1.1 µM, respectively)

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