Foxo1 Inhibitor, AS1842856 - Calbiochem
| Name | Foxo1 Inhibitor, AS1842856 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 344355 |
| Formula | C₁₈H₂₂FN₃O₃ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable oxodihydroquinoline that preferentially inhibits the transcription activity of Forkhead box O family member Foxo1 over that of the functionally related Foxo3a and Foxo4 (70%, 20%, and 3% inhibition, respectively, in HepG2-based reporter assays; [AS184256] = 100 nM) in a dose-dependent manner (IC 50 = 33 nM) via direct binding of the non-Ser256-phosphorylated/active Foxo1, but not the Ser256-phosphorylated/inactive form of Foxo1 |
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