LRRK2 Inhibitor II, CZC-25146 - Calbiochem
| Name | LRRK2 Inhibitor II, CZC-25146 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 438194 |
| Formula | C₂₂H₂₅FN₆O₄S•HCl |
| Purity | ≥98% by HPLC |
| Description | An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC 50 = 4.76 and 6.87 nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC 50 < 300 nM) in a 185-kinase panel |
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