Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem
| Name | Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 574714 |
| Cas Number | 732938-37-8 |
| Formula | C₂₀H₁₈N₆O₃•HCl•H₂O |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC 50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models. |
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