p21 Inhibitor, UC2288 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 532813
• Formula: C₂₀H₁₈ClF₆N₃O₂
• Purity: ≥98% by HPLC
• Description: A cell-permeable phenylcyclohexyl-urea compound that downregulates cellular p21/Cip1/CKI/Waf1 protein level (by > 95% in HCT116 cells after 24 h UC2288 treatment at 2.5 µM), presumably by means of a yet undetermined transcriptional or post-transcriptional regulation without affecting p21 cellular half-life or inhibiting the kinase activities of C-raf, B-raf V600E , or VEGFR2 (IC 50 > 10 µM)