RSK Inhibitor II - CAS 501437-28-1 - Calbiochem
| Name | RSK Inhibitor II - CAS 501437-28-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 559286 |
| Cas Number | 501437-28-1 |
| Formula | C₁₉H₂₃F₂N₅O₂ |
| Purity | ≥95% by HPLC |
| Description | The racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC 50 = 31, 24, 18, and 15 nM against RSK1, 2, 3, and 4, respectively; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC 50 ≥100 nM) and displaying little activity against 39 others |
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