SHIP1 Inhibitor, 3AC - Calbiochem

• Supplier: EMD Millipore
• Catalog: 565835
• Formula: C₂₇H₄₉N
• Purity: ≥98% by 1H NMR
• Description: A cell-permeable steroidal compound that selectively inhibits SHIP1-, but not SHIP2-, catalyzed PI(3,4,5)P3-to-PI(3,4)P2 dephosphorylation (IC 50 = 10 µM vs. >1 mM, respectively), while exhibiting little activity against the PTEN-catalyzed PI(3,4,5)P3-to-PI(4,5)P2 conversion (IC 50 > 1 mM)