USP14 Inhibitor, IU1 - Calbiochem
| Name | USP14 Inhibitor, IU1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 662210 |
| Formula | C₁₈H₂₁FN₂O |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable pyrrolylpyrrolidinyl-ethanone that inhibits the proteasome association-dependent USP14 deubiquitinase (DUB) activity in a reversible manner (IC 50 = 4.7 µM against Ub-AMC hydrolysis), likely by targeting USP14 active site thiol, while exhibiting little or no activity toward 8 other DUBs (<10% inhibition of IsoT, UCH37/UCH-L5, BAP1, UCH-L1, UCH-L3, USP2, USP7, and USP15 at 17 µM) |
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