Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem
| Name | Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 219493 |
| Formula | C₂₅H₂₆N₃O₂S |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC 50 = 12 nM; K i = 7.4 nM) with excellent selectivity over hDAGKα (IC 50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC 50 ≥10 µM) in cell-free enzymatic assays |
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