(5 Z )-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem
| Name | (5 Z )-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 499610 |
| Cas Number | 66018-38-0 |
| Formula | C₁₉H₂₂O₇ |
| Purity | ≥97% by HPLC |
| Description | A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC 50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC 50 = 411 nM) and three other MAPKKKs (IC 50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations |
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