Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem
| Name | Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 539185 |
| Cas Number | 146304-91-8 |
| Formula | C₈H₇NO₂S₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable thienyl-oxathiazolone compound that effectively kills non-replicating Mycobacterium tuberculosis (~320- or 12,600-fold drop in BCG titre over 4 days by 50 µM GL5 with or without 50 µM DETA-NO, respectively) by selectively inhibiting its proteasome activity (by ~90% over 4 hours with 50 µM GL5) in a substrate-competitive and irreversible manner, while exhibiting little activity against trypsin, cathepsin B, MMP-2, or human 20S proteasome β1/2/5 |
| Supplier Page | Shop |
Product images
