Cryptotanshinone - CAS 35825-57-1 - Calbiochem
| Name | Cryptotanshinone - CAS 35825-57-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 233630 |
| Cas Number | 35825-57-1 |
| Formula | C₁₉H₂₀O₃ |
| Purity | ≥95% by HPLC |
| Description | Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr 705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM) |
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