Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
| Name | Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 645890 |
| Cas Number | 347323-96-0 |
| Formula | C₂₂H₁₇N₃OS |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable thiazolo-benzimidazolone compound that inhibits Trio N-terminal RhoGEF domain- (TrioN) mediated RhoG activation (IC 50 = 76 µM) and effectively reduces cellular Rac activation (by 80% with 50 µM ITX3) caused by TrioN, but not GEF337 (RhoA GEF), Tiam1 (Rac GEF), or Vav2 (Rac1/RhoA/Cdc42 GEF), overexpression in HEK293T cells |
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