Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
| Name | Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 322338 |
| Cas Number | 294891-81-9 |
| Formula | C₂₂H₁₈N₂O₄ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain ( K d = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC 50 = 12.5 µM) |
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