| Description |
A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (K i = 1.8 nM), myosin light chain kinase (K i = 20 nM), protein kinase A (K i = 18 nM), protein kinase C (K i = 25 nM), protein kinase G (K i = 20 nM), NGF receptor gp140 trk (IC 50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145 trk B and gp145 trk C. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC 50 <50 nM)
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