Bcr-abl Inhibitor III, GNF-5 - Calbiochem
| Name | Bcr-abl Inhibitor III, GNF-5 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 197224 |
| Formula | C₂₀H₁₇F₃N₄O₃ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable GNF-2 (Cat. No. 197221) N-hydroxyethyl carboxamide analog that exhibits in vivo efficacy in suppressing the proliferation of Bcr-abl-expressing Ba/F3 (93% and 83% of no-treatment control, respectively, on days 5 and 7 post treatment; 100 mg/kg b.i.d.) and bone marrow cells (~75% of no-treatment control in both WBC counts and spleen weight on day 7 post treatment; 50 mg/kg b.i.d.) in murine xenograft models of leukemia |
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