MDMX Inhibitor, NSC207895 - Calbiochem
| Name | MDMX Inhibitor, NSC207895 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 444158 |
| Formula | C₁₁H₁₃N₅O₄ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable benzofuroxan compound that is shown to downregulate the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC 50 = 2.5 µM in HT1080 reporter assays), leading to enhanced p53 stabilization/activation and an upregulation of the p53 downstream gene MDM2 production, which in turn could mediate further cellular MDMX proteolytic degradation |
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