TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
| Name | TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 616461 |
| Cas Number | 301836-41-9 |
| Formula | C₂₂H₁₆N₄O₃.2H₂O |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6 |
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