Akt Inhibitor XV, Isozyme-Selective - Calbiochem

• Supplier: EMD Millipore
• Catalog: 124034
• Formula: C₃₃H₂₉N₇O
• Purity: ≥97% by HPLC
• Description: A cell-permeable naphthyridinone compound that acts as an allosteric Akt1/2-selective inhibitor (IC 50 = 3.5, 42, and 1900 nM against Akt1, Akt2, and Akt3, respectively) in a PH domain-dependent, but not ATP-competitive, manner, with little activity against a panel of more than 160 other kinases, including the related AGC family kinases (inactive at 10 µM against GSK, PDK1, PKA, PKC, and SGK)