| Description |
A cell-permeable CFTR inh -172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR inh -172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR inh -172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC 50 = 1.4 µM vs. 0.38 µM with CFTR inh -172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
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