MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem
| Name | MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 444967 |
| Cas Number | 212631-67-9 |
| Formula | C₁₇H₁₃BrClF₂IN₂O₂ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable, blood-brain barrier permeant, and orally active hydroxamate compound that is reported to inhibit MEK activity (IC 50 = 10-100 nM) without competing against ATP or Erk binding and exhibit excellent selectivity over 27 other cellular kinases, including JNK, MAPK2/ERK2, SAPK2a, SAPK2b, SAPK3, and SAPK4 (IC 50 > 10 µM) |
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