EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
| Name | EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 324832 |
| Cas Number | 196612-93-8 |
| Formula | C₁₈H₁₉ClFN₇•2HCl•2H₂O |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR (ErbB-1, HER-1) both in cell-free enzymatic reactions (IC 50 = 3 nM) and in culture (IC 50 = 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells) |
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