PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem
| Name | PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 526561 |
| Cas Number | 1197160-28-3 |
| Formula | C₂₅H₂₈N₈O₃•H₂O |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable triazinyl-phenyl-pyridinylurea compound that acts as a potent inhibitor against mTOR and PI 3-K activities (IC 50 = 0.42 nM against mTOR; IC 50 = 8, 24, 74, 77, 14, and 11 nM against PI 3-K isoform α, β, γ, δ, α E545K mutant, and α H1047R mutant, respectively), exhibiting much reduced potency against Cytochrome CYP 2C8 (IC 50 = 3 µM) and little or no activity toward 7 other Cytochrome CYP isoforms, hERG (IC 50 >30 µM) and a panel of 361 other kinases (IC 50 >50 µM) |
| Supplier Page | Shop |
Product images
