SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem
| Name | SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 569371 |
| Cas Number | 473-98-3 |
| Formula | C₃₀H₅₀O₂ |
| Purity | ≥95% by NMR |
| Description | A cell-permeable pentacyclic triterpenoid from birch bark extract that interacts with SCAP (SREBP cleavage activating protein) and prevents SREBP (sterol regulatory element-binding protein) Golgi proteolytic activation (1 to 13.55 µM in Rat hepatocytes CRL-1601) via a similar mechanism as oxysterols by inducing the association of SCAP with Insig-1 (insulin-induced gene-1), thereby causing SCAP-SREBPs complex ER retention |
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