InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

Name InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
Supplier EMD Millipore
Catalog 220491
Cas Number 516480-79-8
Formula Suppliedasa25mM(5mg/550µL)solutionofChk2Inhib
Purity ≥95% by HPLC
Description A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC 50 of 15 nM and a K i of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC 50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1
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